In sickle cell Hb, which chain is affected?
Correct answer B. Beta Chain
Topic / 40 questions
Chromosome and DNA MCQs cover the structure of DNA, how it is copied, how chromosomes package it, and the classic experiments that proved DNA is the genetic material. They are aimed at MDCAT and NEET candidates, and every question shows the correct answer the moment you choose an option.
Correct answer B. Beta Chain
Correct answer A. Rosalind Franklin
Correct answer C. Live S type pneumococcus
Correct answer A. Primary constriction
Correct answer D. 80
Correct answer C. Fruitfly
Correct answer B. 8 histones as acidic proteins
Correct answer C. Vernone Ingram
Correct answer B. Phenylalanine hydroxylase
Correct answer C. Coding
Correct answer C. Alteration in sequence of DNA nucleotide
Correct answer D. Both a and b
Correct answer A. Ribosome and aminoacyl-tRNA
Correct answer B. Anticodon
Correct answer B. Tryptophan
Correct answer D. Both b and c
Correct answer B. UGA,UAG,UAA
Correct answer D. Both a and c
Correct answer C. 45
Correct answer D. Both a and b
This topic sits at the heart of molecular biology in entry test syllabi. Questions cover the components of DNA, including deoxyribose sugar, phosphate and the bases adenine, guanine, cytosine and thymine, and the semi-conservative model of replication confirmed by Meselson and Stahl. Griffith's transformation experiment with smooth and rough pneumococcus strains in mice also appears, together with the enzymes of replication in E. coli such as DNA polymerase III. You will also see the gene as a nucleotide sequence coding for a polypeptide and the molecular basis of sickle cell anaemia identified by Vernon Ingram. These facts are frequently tested in medical entry tests.
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Semi-conservative replication means each new DNA molecule contains one original parental strand and one newly made strand. The two strands of the double helix separate, and each acts as a template for a complementary strand. Meselson and Stahl confirmed this model in 1958 using heavy and light nitrogen isotopes in E. coli.
DNA polymerase III is the main enzyme that synthesises new DNA strands during replication in E. coli. DNA polymerase I removes RNA primers and fills the gaps, while DNA ligase joins Okazaki fragments on the lagging strand. Exam questions often test which polymerase does which job.
MCQs360 currently offers 41 Chromosome and DNA MCQs in its MCAT Biology section. You can attempt them free without signing up, and each shows its answer instantly, which helps you revise genetics facts quickly before MDCAT or NEET.
Last reviewed October 2026