In fact, they have some difficulty in adapting their selves to these changes.

1. A Option A: In fact, they have some difficulty in adapting their selves to these changes.
2. B Option B: In fact, they have some difficulty in adopting themselves to these changes.
3. C Option C: In fact, they have some difficulty in adapting their selves to these changes.
4. D Option D: In fact, they have some difficulty in adapting themselves to these changes.

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