What is the correct order of reactivity of acid derivatives towards nucleophilic acyl substitution?
Correct answer C. Acyl chloride > anhydride > ester > amide
Explanation
Reactivity depends on how well the leaving group departs. Cl⁻ is the best leaving group and NH₂⁻ the worst, while resonance donation by nitrogen makes amides least reactive. So acyl chlorides are most reactive and amides least.
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